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5 The effects and their mechanism of bilirubin on tumors 5.1 Tumor inhibitory effects of bilirubin 5.1.1 Bilirubin inhibits oxidative stress to suppress tumor development In normal physiological circumstances, the presence of antioxidants counteracts the reactive oxygen species (ROS), resulting in a balance (53), while oxidative stress is a situation when the balance is disrupted

The latter enrolled 190 patients with obesity (mean age 54.4 years, mean BMI 36.1 kg/m 2 ) and biopsy-proven MASH and moderate-to-severe fibrosis regardless of the presence of T2D, showing a BW reduction of 10.7%, 13.3%, 15.6% and 0.8% at 52 weeks with tirzepatide 5 mg, 10 mg, 15 mg and placebo, respectively 39